Three New Cytotoxic Withanolides from the Chinese Folk Medicine Physalis angulata
نویسندگان
چکیده
منابع مشابه
Cytotoxic withanolides from Vietnamese ethno-medicinal plant Physalis angulata
Withanolides are known as the main components of Physalis genus with broad biological activities. Using combination of various chromatographic methods, three withanolides were isolated including physagulin J (1), physagulin K (2), and physagulin N (3). Their chemical structures were determined by analysis of NMR spectra, and as well as comparison with reported literature. Compound 1 showed sign...
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Nine new withanolides (1-9), withahisolides A-I, were isolated along with nine known compounds (10-18) from the aerial parts of Physalis hispida. The structures of 1-9 were elucidated through a variety of spectroscopic techniques, while the structures of 1 and 2 were confirmed by X-ray crystallographic analysis. Compounds 1-3 are the first withanolides with nonaromatic six-membered ring D moiet...
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Six withanolides (1-6), as well as two known withanolides (physachenolide D 7 and withanoside VI 8), were isolated from the aerial parts of Physalis coztomatl (Solanaceae). Structural elucidations of 1-6 were achieved through 2D NMR and other spectroscopic techniques, while the structure of 1 was confirmed by X-ray crystallographic analysis. In addition, the stereochemical orientation of the 17...
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Physalis pubescens L. plant produces nutritious and healthy fruits, called husk tomato or hairy ground cherry. However, its bioactive components are largely unknown. Four new withanolide steroids (1-4) together with one known withanolide (5) were isolated from the extract of P. pubescens L. and their chemical structures were established by extensive spectroscopic analyses. Compounds 1, 3 and 5 ...
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Four withanolides (1-4) and two sucrose esters (5, 6) were isolated from the aerial parts of Physalis neomexicana. The structures of 1-6 were elucidated through a variety of spectroscopic techniques. Cytotoxicity studies of the isolates revealed that 2 inhibited human breast cancer cell lines (MDA-MB-231 and MCF-7) with IC50 values of 1.7 and 6.3 μM, respectively.
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ژورنال
عنوان ژورنال: Natural Product Communications
سال: 2015
ISSN: 1934-578X,1555-9475
DOI: 10.1177/1934578x1501001211